Djamil General Hospital Research Articles

The Profile of Sinonasal Tumors with Orbital Involvement in Dr. M. Djamil General Hospital, Padang, Indonesia: A 10-Year Overview

Background: Sinonasal tumors are rare tumors, either malignant or benign, that vary greatly based on the origin and primary tumor location in the sinonasal tract. The close anatomical relationship between the sinonasal tract and the orbital cavity makes orbital involvement very common (50%-80%) in sinonasal tumors, and this indicates a negative prognostic factor in sinonasal malignancy. The purpose of this study is to demonstrate the profile of sinonasal tumors with orbital involvement in our center.
 Methods: Retrospective study from oncology subdivision files and medical records from January 2011 – December 2020. Collected data including age, gender, the clinical manifestations of orbital involvement, primary location, histopathology, and management of sinonasal tumors.
 Results: There were 35 patients examined by the oncology subdivision either directly came or consulted from the ENT department, consisting of 18 (51.4%) males and 17 (48.6%) females. The age of patients ranged from 11 to 83 years old. with the most common age groups being 41-50 and 51-60 (25.7% in each age group). The majority of the patients (77.1%) had presented with proptosis. Maxillary sinus was the most common (45.7%) primary site of tumors, and squamous cell carcinoma was the most common (51.4%) histopathology found. Most of the patients (37.1%) were treated with a combination of chemotherapy and radiotherapy.
 Conclusion: Orbital involvement commonly occurs in malignant sinonasal tumors with proptosis as a major clinical presentation. A combination of chemotherapy and radiotherapy was the most common practice management because the tumors were unresectable at the time of presentation.

Effect of Diagnosis, Complications, and Nutrition for Using Nasogastric Tube to Body Weight of Child Patients with Feeding Difficulty at Dr. M. Djamil General Hospital, Padang, Indonesia

Background: Several conditions in children can cause nutritional intake via the oral route to be inadequate. Providing enteral nutrition via a nasogastric tube (NGT) is an alternative option. Research on the use of NGTs in Indonesia is still limited, so this research aims to determine the effect of NGT use on the weight of pediatric patients with feeding difficulties at Dr. M. Djamil General Hospital, Padang.
 Methods: Experimental research with a pre and post-test-only design was conducted on 96 children aged 1 month - 18 years in the children's inpatient room at Dr. M. Djamil General Hospital, Padang. Body weight measurements were carried out before and after using NGT for 4 weeks (January 2022 – January 2023) at the pediatric nutrition and metabolic diseases polyclinic. Data were analyzed using paired t-test and ANOVA.
 Results: Most subjects (40.9%) were in the 1-12 month age group. The most common type of nutrition was ONS (oral nutritional supplements) (84.4%), the most common diagnosis was pulmonology (33.3%), and the majority were without complications (72.9%). There is an influence on the child's weight before and after using NGT (p-value <0.01). Significant differences were also found in changes in children's weight with diagnosis and complications (p<0.01).
 Conclusion: The use of NGT can increase the weight of pediatric patients who have feeding difficulties at Dr. M. Djamil General Hospital, Padang. Significant differences were found in changes in children's weight by diagnosis and complications.

The Influence of Human-AI Interaction in the Decision-Making Process in the Health Sector: A Study at Dr. M. Djamil General Hospital, Padang, Indonesia

Artificial intelligence (AI) plays an increasingly important role in the health sector, including in the decision-making process. Human-AI interaction can help doctors diagnose diseases, provide treatment recommendations, and improve the quality of patient care. This research uses experimental studies to investigate the influence of human-AI interactions in the decision-making process in the health sector. Two groups of doctors were included: a group that used AI to aid decision making and a control group that did not use AI. The research results showed that the group of doctors who used AI had better performance in terms of diagnostic accuracy, time efficiency and patient satisfaction. Human-AI interaction can help doctors make better decisions and improve the quality of patient care.

Comparison of the Effectiveness of Total Intravenous Anesthesia (TIVA) vs Inhalation Techniques in Patients with Morbid Obesity at Dr. M. Djamil General Hospital, Padang, Indonesia

Introduction: Morbidly obese patients (BMI ≥ 40 kg/m²) present unique challenges in anesthesia. Total intravenous anesthesia (TIVA) and inhalation techniques have their respective advantages and disadvantages in this group of patients. This study aims to compare the effectiveness and safety of TIVA and inhalation anesthesia in morbidly obese patients at Dr. M. Djamil General Hospital Padang.
 Methods: A prospective, randomized study was conducted on 80 morbidly obese patients undergoing elective surgery. Patients were randomized to receive TIVA with propofol and remifentanil or inhalation anesthesia with sevoflurane and desflurane.
 Results: The TIVA group demonstrated faster recovery time (p = 0.02) and less postoperative opioid requirements (p = 0.01) than the inhalation group. There was no significant difference in the incidence of intraoperative or postoperative complications.
 Conclusion: TIVA is an effective and safe option for morbidly obese patients undergoing elective surgery. TIVA offers faster recovery and fewer postoperative opioid requirements than inhalation anesthesia.

Multiple Choledochal Cysts: A Case Report

Background: Choledochal cysts (CC) are congenital dilatations of the biliary tree, characterized by varying degrees of cystic dilatation at various segments of the biliary tract (extrahepatic or intrahepatic), may be detected at any age and in any portion of the bile duct. This study was aimed to present the management of multiple choledochal cyst case.
 Case presentation: A 9 year old boy was brought by his mother to the emergency department at Dr. M. Djamil General Hospital Padang with chief complaint abdominal pain that’s getting worse 2 weeks before admission. Abdominal pain first complained by the patient since age of 4, the pain was felt all over stomach area, not localized, not radiated, not corelated with meal time, colicky, relieved with paracetamol. USG results: Choledochal cyst, Helicobacter pylori infection, elevated liver enzymes due to suspect suppression of choledochal cyst. Abdominal CT-Scan with contrast results: Intrahepatic and extrahepatic choledochal cyst (type IV A).
 Conclusion: Patients was diagnosed with multiple choledochal cysts, diffuse peritonitis, Helicobacter pylori infection, and familial short stature.

The Impact of COVID-19 Pandemic on Vitiligo Patient Visits in Tertiary Hospital: A Retrospective Study

Background: Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of the population worldwide. The COVID-19 pandemic lockdown measures significantly affected the readiness of vitiligo patients to contact dermatologists. The aim of this study is to describe vitiligo patient visits during a pandemic situation.
 Methods: A retrospective descriptive study, using secondary data obtained from Dr. M. Djamil General Hospital Padang medical records during the period of 2019–2021.
 Results: During the pandemic (2020-2021), a total of 7 in 2020 and 19 in 2021 new vitiligo patient have been consulted. The ratio of male/female for two years was 16/10. The age of group 26-24 years had more frequently visited. A total 6 patients had segmental vitiligo and 16 patients had non segmental vitiligo. A total 4 patient had unstable vitiligo. During the pandemic, there were various vitiligo therapy such as oral and topical corticosteroid, topical immunomodulator, phototherapy, and punch grafting surgery. Compare to   before the pandemic situation in 2019, a total 25 new vitiligo patient have been consulted in our outpatient clinic. Compared to 2019, the number of visits decrease significantly 72% in 2020 and 24% in 2021.
 Conclusion: The pandemic COVID-19 had an unprecedented impact on number of vitiligo patient visits to the tertiary hospitals. This condition may affect visits and patient compliance. There were significant reductions in the number of outpatient visits due to pandemic COVID-19.

Relationship Between D-Dimer, Albumin Levels, and Outcome of COVID-19 Patients at Dr. M. Djamil General Hospital, Padang

Background: Several studies have found an increase in D-dimer levels in patients who died from a severe clinical condition. COVID-19 exhibits multi-organ dysfunction through several markers, including decreased albumin levels. There were some studies that were interested in understanding how D-dimer and albumin levels relate to the outcomes of COVID-19 patients. The aim of this study was to investigate the relationship between D-dimer, albumin levels, and patient outcomes. Method: This was a cross-sectional study of all COVID-19 patients treated at Dr. M. Djamil General Hospital, Padang, from January 1st, 2021 to December 31st, 2021. Results: The majority of patients (40.71%) were in the group of 18 and 49 years old; more than half of the subjects (56.16%) were female; and obesity was the most common comorbidity (40.9%). The majority of the subjects (42.79%) had moderate clinical COVID-19. Higher D-dimer levels had a statistically significant independent relationship with unfavorable outcomes (P=0.0001). Lower albumin levels had a statistically significant independent relationship with unfavorable outcomes (P=0.0001). Higher D-dimer and lower albumin each contributed 12.6% to patient outcome. Increasing D-dimer levels per 1 ng/mL would increase the probability of an unfavorable outcome by 0.120 times, and on the other hand, increasing albumin levels per 1 g/dL would increase the probability of survival by 2.143 times. Conclusion: Higher D-dimer levels independently had a relationship with an unfavorable outcome. Higher albumin levels were independently related to a favorable outcome.

A Study of Potential Drug-Drug Interactions in Peptic Ulcer Patients in Dr. M. Djamil Hospital Padang in 2019

A peptic ulcer is a gastrointestinal tract disorder caused by excessive secretion of acid and pepsin by the gastric mucosa. The combined use of drugs in peptic ulcer management may potentially cause drug-to-drug interactions. Drug interactions are caused when two or more drugs interact and may affect the effectiveness of the other drugs. This study aims to analyze the potential drug reactions in peptic ulcer patients in the internal medicine ward of Dr. M. Djamil General Hospital Padang in 2019. This study was a descriptive, non-experimental study with retrospective data, while data analysis used Drugs.com and Medscape applications. The study results revealed that 29 patients fit the inclusion criteria and 5 (16.6%) potential drug pharmacokinetic interactions. The severity of drug interactions shows 4 cases (80%) with moderate severity potential and 1 case (20%) with minor severity potential. The study concluded that there were potential drug interactions in peptic ulcer patients in the internal medicine ward of Dr. M. Djamil General Hospital Padang in 2019.

Peripartum Cardiomyopathy: A Case Report

Background: Peripartum cardiomyopathy (PPCM) is a type of dilated cardiomyopathy of unknown origin. Predisposing factors for PPCM are multiparity, family history, ethnicity, smoking, diabetes, hypertension, preeclampsia, malnutrition, and advanced age in pregnant women or teenage pregnancy.
 Case presentation: A 29-year-old female patient was treated in the internal medicine department of Dr. M. Djamil General Hospital Padang on March 18th, 2023, with the main complaint of shortness of breath. On physical examination, signs of congestion were found. ECG shows sinus tachycardia, QT prolongation, and T inversion in V3-V6, II, III, and aVF. The patient is established with peripartum cardiomyopathy, community-acquired pneumonia, nonsevere low-risk MDR, hypochromic microcytic mild anemia et causa chronic disease, high-risk VTE, h hypokalemia et causa diuretic.
 Conclusion: Education regarding recurrent recurrence of PPCM in subsequent pregnancies is 30-50%. The prognosis depends on the recovery of left ventricular function; 30% of patients can return to baseline ventricular function within 6 months, and 50% of patients have an improvement in symptoms and ventricular function. Contraception is recommended that does not pose a risk of thromboembolism, such as a uterine device (IUD) and subcutaneous progesterone.

Embryonal Rhabdomyosarcoma: Rare Case Reports with Middle Ear Location

Background: Patients with embryonal rhabdomyosarcoma (EMRS) are dominated by boys. The peak incidence occurs in the small age group from one year to 4 years. Approximately 35% of all pediatric RMS occur in the head and neck.
 Case presentation: A 3-year-old male patient came to the ear, nose, throat-head neck (ENT-HNS) polyclinic at Dr. M. Djamil General Hospital Padang on February 25th, 2021, with complaints of a lump appearing in his right ear canal for 4 months. The patient also complained of slanting on the right side of his face and pain in his right ear since 2 weeks ago. History of bleeding from the ear 1 week ago. On the examination of House-Brackmann, the patient obtained a category House-Brackmann V. Histopathological results, microscopically visible pieces of tissue with part of the surface covered with keratinized squamous epithelium, part of the surface not keratinized. There are dense groups consisting of a proliferation of cells with round, oval nuclei, small to medium size, little cytoplasm, some cells with pleomorphic nuclei, hyperchromatic, irregular nuclear membranes, lots of eosinophilic cytoplasms, with the appearance of "tadpole”, atypical mitoses may be found. The underlying tissue stroma appears myxoid. Among them, fibrotic connective tissue septa containing partially hyperemic capillaries are visible. Necrotic areas and clusters of PMN leukocytes and cellular debris were also seen. This description is consistent with EMRS.
 Conclusion: The patient was diagnosed with right middle ear EMRS stage III with right peripheral facial nerve paresis House-Brackmann V.

Factors Affecting the Mortality of Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass at Dr. M. Djamil General Hospital, Padang, Indonesia

Background:  Morbidity and mortality of patients after cardiac surgery can be influenced in the preoperative, intraoperative, and postoperative periods. This study aimed to explore factors that affect the mortality of patients undergoing open heart surgery with cardiopulmonary bypass at Dr. M. Djamil General Hospital, Padang, Indonesia.
 Methods: This study is an analytical observational research with a cross-sectional approach and uses secondary data obtained from the medical record installation of Dr. M. Djamil General Hospital, Padang, Indonesia. A total of 57 research subjects participated in this study. Univariate, bivariate, and multivariate analyses were carried out using SPSS software.
 Results: The final multivariate modeling results show that the variables that influence patient mortality are EuroSCORE II (p-value=0.003) and duration of CPB (p-value=0.003). With an odds ratio of 37.21 groups, EuroSCORE II high risk had a risk of death 37.21 times higher than the low-risk group (CI 3.325 – 416.324). Meanwhile, increasing the duration of CPB by one minute increased the risk of mortality 1.02 times (CI 1.006 – 1.030). Meanwhile, there is no influence of variables (NYHA, LV function, ACC duration) on the incidence of mortality in patients undergoing open heart surgery with a machine cardiopulmonary bypass at Dr. M. Djamil General Hospital, Padang.
 Conclusion: EuroSCORE II affects the mortality of patients undergoing open heart surgery with CPB. The duration of CPB affects the mortality of patients undergoing open heart surgery with CPB.

The Relationship between Neutrophil-Lymphocyte Ratio to Intestinal Viability in Invagination Patients at Dr. M. Djamil General Hospital, Padang, Indonesia

Background: Invagination is an acute condition in the pediatric abdomen that results in obstruction and constriction of blood vessels (strangulation) in the proximal intestinal mesenterium trapped in the distal intestine, allowing necrosis of surrounding tissue. Intestinal necrosis and perforation in children are causes of abdominal emergencies that require immediate surgery. In supporting examinations, neutrophil, lymphocyte, and biomarker combination ratios have been used for early detection of systemic inflammatory markers. The threshold value of several biomarkers should be investigated to assess the occurrence of strangulation in the pre-operative period in invaginated patients. This study aimed to determine the relationship between neutrophil-lymphocyte ratio and intestinal viability in pediatric patients with invagination.
 Methods: This study used retrospective analytic data collection from medical records of invagination patients at Dr. M. Djamil General Hospital Padang for the period January 1, 2020, to December 31, 2022.
 Results: The majority of subjects were male (53.8%) at the age of ≤ 1 year, with as many as 87.2% having a diagnosis of operative invagination (76.9%) and 56.4% having intestinal viability. The mean neutrophil, lymphocyte, and NLR values were 62.15±17.68, 19.03±8.97, and 3.74±1.55, respectively. The pathological NLR status was found to be 59%. The p-value for the association of diagnosis with intestinal viability was 0.002. The p-value for the relationship between NLR and intestinal viability was 0.001, and the r-calculated was -0.528.
 Conclusion: There is a significant relationship between NLR value and disease diagnosis on intestinal viability.

The Relationship between Plasma Glutamate Levels and Sleep Quality in HIV Patients

Background: Disturbance sleep quality is often found in sufferers of human immunodeficiency virus (HIV). Disturbed sleep quality can affect immunity, which ultimately can increase patient morbidity and mortality. Impaired sleep quality in HIV sufferers is related to neurotoxicity due to the HIV virus, which damages sleep architecture. HIV infection can cause an increase in brain extracellular glutamate. Elevated glutamate plays a role in neuronal and glial damage and death. This study aimed to assess the relationship between plasma glutamate levels and sleep quality in HIV sufferers.
 Methods: The research uses a cross-sectional design. The samples were HIV sufferers in a polyclinic voluntary counseling test (VCT) internal medicine of Dr. M. Djamil General Hospital Padang, who met the inclusion and exclusion criteria. Samples are selected by consecutive methods. Sleep quality was assessed using a questionnaire called the Pittsburgh sleep quality index (PSQI). Plasma glutamate levels were measured using the ELISA method. Statistical analysis using SPSS with a p-value <0.05 was considered statistically significant.
 Results: The research sample consisted of 82 people. The median plasma glutamate level was 16.39 µg/mL. Impaired sleep quality was found in 45 (54.9%) HIV sufferers. There was no significant relationship between plasma glutamate levels (p= 0.506), age (p=0.795), gender (p=0.547), education (p=0.358), occupation (p=0.255), disease duration (p=0.348), stage (p=0.309) and type of ARV therapy (p=0.791) with sleep quality in HIV sufferers. From this research, a significant relationship was found between sleep quality, body mass index (BMI) (p= 0.015), and marital status (p= 0.039).
 Conclusion: There is no relationship between plasma glutamate levels and sleep quality in HIV sufferers. There are other factors that influence sleep quality, namely BMI and marital status.

The Difference of Survival Rate COVID-19 in Patients with Initiated Hemodialysis and Regularly Hemodialysis

Background: Since December 2019, a novel coronavirus called SARSCoV-2 (severe acute respiratory syndrome coronavirus) has caused an international outbreak of respiratory illness described as COVID-19. This study aimed to describe the difference in the survival rate of COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis in Dr. M Djamil General Hospitals. Also, in this review, we provide a comprehensive overview of data on the factors that may be affected by COVID-19 survival rates in patients with COVID-19 induced AKI with hemodialysis and COVID-19 in patients with CKD on hemodialysis. This study was conducted to analyze the survival of COVID-19 with initiated or regular HD patients in Dr. M. Djamil General Hospital, Padang, Indonesia.
 Methods: This study was conducted from January 2021 to July 2021 in Dr. M. Djamil General Hospital, Padang, West Sumatera, Indonesia. Data for this study was collected through medical records of patients admitted for COVID-19 with CKD in hemodialysis and acute renal failure induced by COVID-19 to show the demographics, comorbidities, and survival rates of the patients who underwent hemodialysis.
 Results:  Factors associated with survival in COVID-19 with hemodialysis were COVID-19 severity and abnormal potassium serum level (Table 3).  Moderate COVID-19 patients tend to survive than severe COVID-19 patients (OR 60; 95% CI 16.034 – 224.525). There was no significant difference in survival between initiated and regular HD (p = 0.829).
 Conclusion: There is no difference in clinical outcome from patients with COVID-19 who initiated hemodialysis or regularly HD to the survival rates.

The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients.

Vitamin D plays crucial roles in immune cell function, including macrophage activation, immune response modulation, and antimicrobial peptide production. Low vitamin D levels can result in reduced immune response, heightened inflammation, and impaired organ function, thereby exacerbating sepsis severity and impacting patient prognosis. This study investigates the influence of vitamin D binding protein expression and vitamin D levels on the mortality of septic patients. This analytical observational study employs a case-control approach and involves patients at the Critical Care Unit of Dr. M. Djamil General Hospital in Padang, Indonesia. The study comprises 40 patients in the case group and 40 patients in the control group. Vitamin D and vitamin D binding protein levels are assessed using the enzyme-linked immunosorbent assay method. Vitamin D and vitamin D binding protein levels were observed to be lower in the case group compared to the control group. In the case group, the majority of patients had vitamin D binding protein levels below 200 µg/mL. A significant association was found between vitamin D levels and mortality in sepsis patients (P< 0.05). Patients with vitamin D levels below 20 µg/mL faced a 2.54 times higher risk of mortality than those with levels exceeding 20 µg/mL. Diminished levels of vitamin D binding protein and vitamin D contribute to an increased risk of mortality in septic patients.

EP16.14: Placenta accreta spectrum disorder, an obstetrical challenge: a case series at a tertiary hospital (M Djamil General Hospital Padang) in Indonesia

EP16.14: Placenta accreta spectrum disorder, an obstetrical challenge: a case series at a tertiary hospital (M Djamil General Hospital Padang) in Indonesia

EP16.28: Descriptive study of placenta accreta cases in M Djamil General Hospital Padang (a tertiary hospital) in Indonesia in 2022

EP16.28: Descriptive study of placenta accreta cases in M Djamil General Hospital Padang (a tertiary hospital) in Indonesia in 2022

Comparison of Outcomes in Patients with Malignant Pleural Efusion et Causa Breast Cancer Metastase Thought of Pleurodesis with Talc Poudrage and Talc Slurry at Dr. M. Djamil General Hospital, Padang, Indonesia

Background: Breast cancer accounts for about 50-65% of malignant pleural effusions. Talc pleurodesis is one of the definitive procedures for pleural effusions in which the route of administration is divided into poudrage and slurry. This study aimed to compare the differences of outcomes in malignant pleural effusion patients et causa breast cancer metastase who receive pleurodesis therapy with talc poudrage and talc slurry.&#x0D; Methods: This study has a cross-sectional design, which was conducted at Dr. M. Djamil General Hospital in May – July 2023. This study used medical records of patients diagnosed with malignant pleural effusion due to metastases of breast cancer at Dr. M. Djamil General Hospital Padang from January 2019 – July 2023. The outcomes assessed included drain production in 24 hours, drain release time, and in-hospital mortality.&#x0D; Results: In this study, 12 respondents who have talc poudrage and talc slurry pleurodesis were included. In the talc poudrage group, the mean of 24-hour drain production was 259.17 ± 46.79 ml, the mean of drain release time was 4.08 ± 0.66 days, and there was one respondent who died during hospitality. In the talc slurry group, the mean of 24-hour drain production was found to be more (420.83 ± 78.21 ml), drain release time was found to be much longer (5.67 ± 0.98 days), and 3 respondents died in hospital. The bivariate analysis found a significant difference between the 24-hour drain production and drain release time of patients who underwent talc slurry and talc poudrage meanwhile there was no difference in hospital mortality.&#x0D; Conclusion: Talc poudrage has a better outcome than talc slurry regarding drain production and drain release time in patients with malignant pleural effusion due to metastases of breast cancer.

Indoxyl Sulphate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients

Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate. Although it's known that indoxyl sulfate has harmful effects on intra or extra-kidney organs, its impact on executive function remains unclear. This study aimed to evaluate indoxyl sulfate levels in patients with chronic kidney disease (CKD) undergoing hemodialysis and to understand its correlation with executive function impairments. This observational cross-sectional study was conducted at the Dr. M. Djamil General Hospital Padang Hemodialysis Unit from March to July 2022; 60 patients undergoing hemodialysis and 20 healthy controls participated. Executive function was assessed using the Trail Making Test B (TMT-B). Indoxyl sulfate levels were quantified using an ELISA assay with the Assay Genie kit. The Mann-Whitney test set statistical significance at a p&lt;0.05. The average age of the subjects was 51.4±11.4 years, with 53.3% being male. The mean indoxyl sulfate levels were considerably higher in the CKD group (118.79 ng/mL, range: 11–1,709 ng/mL) compared to the control group (6.028±1.829 ng/mL), with a significant difference (p&lt;0.001). Impaired executive function was observed in 75% of the CKD patients. The average indoxyl sulfate level was 165.12 ng/mL (range: 29–1709 ng/mL) in the impaired executive function group and 71.22 ng/mL (range: 11–333 ng/mL) in the group with normal executive function, indicating a significant difference (p=0.013). Patients with CKD undergoing hemodialysis exhibit elevated serum indoxyl sulfate levels compared to healthy individuals. Moreover, CKD patients with impaired executive function have notably higher indoxyl sulfate levels than those with normal executive function. Further research is needed to elucidate the mechanistic links between indoxyl sulfate and cognitive impairments.

Comparing the Optical Coherence Tomography Outcomes of Intravitreal Injection Anti Vascular Endothelial Growth Factor in Branch Retinal Vein Occlusion (BRVO)

Background: BRVO is a blockage of the branches of the retinal vein due to a thrombus. The prevalence of 10-year BRVO is 1.6 per 100 subjects. The effect of anti-VEGF injection on BRVO management is effective in improving visual acuity and reducing macular oedema.&#x0D; Case presentation: A man, 32 years old, presented to the ophthalmology clinic at the Dr. M. Djamil General Hospital with a chief complaint of blurred vision in his left eye 1 week before admission. The blurred vision began suddenly. Visual acuity in LE was 20/50 and did not advance with a pinhole. Funduscopic examination of LE showed clear media, rounded papillae with well-defined borders, blood vessels aa:vv = 1:3, venous tortuosity (+) increased in the inferotemporal quadrant; retina: Bleeding (+) with dot blot and flame-shaped inferiorly, exudate (+) cotton wool spots at the inferotemporal region; foveal reflex (+)↓ on the macula. OCT LE examination showed macular intraretinal hypo-reflection and macular thickening with a central macular thickness of 617 μm. The physical examination showed a body weight of 114.9 kg, a height of 173 cm, and a body mass index of 38.4. Within 5 months after 3 times administrations of intravitreal injections of anti-VEGF bevacizumab and ranibizumab, visual acuity of LE: 20/25 was obtained, and increased appearance of the retinal fundus and OCT LE.&#x0D; Conclusion: Intravitreal injection therapy of anti-VEGF bevacizumab and ranibizumab is effective in reducing macular oedema and restoring visual acuity in BRVO.